Publications

  1. Buki, A., N. Kovacs, E. Czeiter, K. Schmid, R.P. Berger, F. Kobeissy, D. Italiano, R.L. Hayes, F.C. Tortella, E. Mezosi, A. Schwarcz, A. Toth, O. Nemes, and S. Mondello, Minor and repetitive head injury. Adv Tech Stand Neurosurg, 2015. 42: p. 147-92.
  2. Carman, A.J., R. Ferguson, R. Cantu, R.D. Comstock, P.A. Dacks, S.T. DeKosky, S. Gandy, J. Gilbert, C. Gilliland, G. Gioia, C. Giza, M. Greicius, B. Hainline, R.L. Hayes, J. Hendrix, B. Jordan, J. Kovach, R.F. Lane, R. Mannix, T. Murray, T. Seifert, D.W. Shineman, E. Warren, E. Wilde, H. Willard, and H.M. Fillit, Expert consensus document: Mind the gaps-advancing research into short-term and long-term neuropsychological outcomes of youth sports-related concussions. Nat Rev Neurol, 2015. 11(4): p. 230-44.
  3. Carr, W., A.M. Yarnell, R. Ong, T. Walilko, G.H. Kamimori, U. da Silva, R.M. McCarron, and M.L. LoPresti, Ubiquitin carboxy-terminal hydrolase-l1 as a serum neurotrauma biomarker for exposure to occupational low-level blast. Front Neurol, 2015. 6: p. 49.
  4. Huang, X.J., O. Glushakova, S. Mondello, K. Van, R.L. Hayes, and B.G. Lyeth, Acute Temporal Profiles of Serum Levels of UCH-L1 and GFAP and Relationships to Neuronal and Astroglial Pathology following Traumatic Brain Injury in Rats. J Neurotrauma, 2015.
  5. McMahon, P.J., D.M. Panczykowski, J.K. Yue, A.M. Puccio, T. Inoue, M.D. Sorani, H.F. Lingsma, A.I. Maas, A.B. Valadka, E.L. Yuh, P. Mukherjee, G.T. Manley, D.O. Okonkwo, S.S. Casey, M. Cheong, S.R. Cooper, K. Dams-O'Connor, W.A. Gordon, A.J. Hricik, K. Lawless, D. Menon, D.M. Schnyer, and M.J. Vassar, Measurement of the Glial Fibrillary Acidic Protein and Its Breakdown Products GFAP-BDP Biomarker for the Detection of Traumatic Brain Injury Compared to Computed Tomography and Magnetic Resonance Imaging. J Neurotrauma, 2015. 32(8): p. 527-33.
  6. Mondello, S. and R.L. Hayes, Biomarkers. Handb Clin Neurol, 2015. 127: p. 245-65.
  7. Papa, L., M.K. Mittal, J. Ramirez, M. Ramia, S. Kirby, S. Silvestri, P. Giordano, K. Weber, C.F. Braga, C.N. Tan, N.J. Ameli, M. Lopez, and M.R. Zonfrillo, In Children and Youth With Mild and Moderate Traumatic Brain Injury GFAP Out-performs S100beta In Detecting Traumatic Intracranial Lesions On CT. J Neurotrauma, 2015.
  8. Papa, L., C.S. Robertson, K.K. Wang, G.M. Brophy, H.J. Hannay, S. Heaton, I. Schmalfuss, A. Gabrielli, R.L. Hayes, and S.A. Robicsek, Biomarkers improve clinical outcome predictors of mortality following non-penetrating severe traumatic brain injury. Neurocrit Care, 2015. 22(1): p. 52-64.
  9. Toth, A., I. Schmalfuss, S.C. Heaton, A. Gabrielli, H.J. Hannay, L. Papa, G.M. Brophy, K.K. Wang, A. Buki, A. Schwarcz, R.L. Hayes, C.S. Robertson, and S. Robicsek, Lateral Ventricle Volume Asymmetry Predicts Midline Shift in Severe Traumatic Brain Injury. J Neurotrauma, 2015.
  10. Yokobori, S., Z. Zhang, A. Moghieb, S. Mondello, S. Gajavelli, W.D. Dietrich, H. Bramlett, R.L. Hayes, M. Wang, K.K. Wang, and M.R. Bullock, Acute Diagnostic Biomarkers for Spinal Cord Injury: Review of the Literature and Preliminary Research Report. World Neurosurg, 2015. 83(5): p. 867-878.
  11. Adams, S., J.A. Condrey, H.W. Tsai, S.I. Svetlov, and P.W. Davenport, Respiratory responses following blast-induced traumatic brain injury in rats. Respir Physiol Neurobiol, 2014. 204: p. 112-9.
  12. Barnea, E.R., D.M. Lubman, Y.H. Liu, V. Absalon-Medina, S. Hayrabedyan, K. Todorova, R.O. Gilbert, J. Guingab, and T.J. Barder, Insight into PreImplantation Factor (PIF*) mechanism for embryo protection and development: target oxidative stress and protein misfolding (PDI and HSP) through essential RIPK binding site. PLoS One, 2014. 9(7): p. e100263.
  13. Chalak, L.F., P.J. Sanchez, B. Adams-Huet, A.R. Laptook, R.J. Heyne, and C.R. Rosenfeld, Biomarkers for severity of neonatal hypoxic-ischemic encephalopathy and outcomes in newborns receiving hypothermia therapy. J Pediatr, 2014. 164(3): p. 468-74 e1.
  14. de Rezende, V.B., D.V. Rosa, C.M. Comim, L.A. Magno, A.L. Rodrigues, P. Vidigal, A. Jeromin, J. Quevedo, and M.A. Romano-Silva, NCS-1 deficiency causes anxiety and depressive-like behavior with impaired non-aversive memory in mice. Physiol Behav, 2014. 130: p. 91-8.
  15. Diaz-Arrastia, R., K.K. Wang, L. Papa, M.D. Sorani, J.K. Yue, A.M. Puccio, P.J. McMahon, T. Inoue, E.L. Yuh, H.F. Lingsma, A.I. Maas, A.B. Valadka, D.O. Okonkwo, and G.T. Manley, Acute biomarkers of traumatic brain injury: relationship between plasma levels of ubiquitin C-terminal hydrolase-L1 and glial fibrillary acidic protein. J Neurotrauma, 2014. 31(1): p. 19-25.
  16. Douglas-Escobar, M.V., S.C. Heaton, J. Bennett, L.J. Young, O. Glushakova, X. Xu, D.Y. Barbeau, C. Rossignol, C. Miller, A.M. Old Crow, R.L. Hayes, and M.D. Weiss, UCH-L1 and GFAP Serum Levels in Neonates with Hypoxic-Ischemic Encephalopathy: A Single Center Pilot Study. Front Neurol, 2014. 5: p. 273.
  17. Glushakova, O.Y., D. Johnson, and R.L. Hayes, Delayed increases in microvascular pathology after experimental traumatic brain injury are associated with prolonged inflammation, blood-brain barrier disruption, and progressive white matter damage. J Neurotrauma, 2014. 31(13): p. 1180-93.
  18. Guingab-Cagmat, J.D., E.B. Cagmat, F.H. Kobeissy, and J. Anagli, Uses and challenges of bioinformatic tools in mass spectrometric-based proteomic brain perturbation studies. Int J Bioinform Res Appl, 2014. 10(1): p. 27-42.
  19. Hacke, W., P.D. Schellinger, G.W. Albers, N.M. Bornstein, B.L. Dahlof, R. Fulton, S.E. Kasner, A. Shuaib, S.P. Richieri, S.G. Dilly, J. Zivin, and K.R. Lees, Transcranial laser therapy in acute stroke treatment: results of neurothera effectiveness and safety trial 3, a phase III clinical end point device trial. Stroke, 2014. 45(11): p. 3187-93.
  20. Kobeissy, F.H., M.C. Liu, Z. Yang, Z. Zhang, W. Zheng, O. Glushakova, S. Mondello, J. Anagli, R.L. Hayes, and K.K. Wang, Degradation of betaII-Spectrin Protein by Calpain-2 and Caspase-3 Under Neurotoxic and Traumatic Brain Injury Conditions. Mol Neurobiol, 2014.
  21. Mannix, R., M. Eisenberg, M. Berry, W.P. Meehan, 3rd, and R.L. Hayes, Serum biomarkers predict acute symptom burden in children after concussion: a preliminary study. J Neurotrauma, 2014. 31(11): p. 1072-5.
  22. Mondello, S., K. Schmid, R.P. Berger, F. Kobeissy, D. Italiano, A. Jeromin, R.L. Hayes, F.C. Tortella, and A. Buki, The challenge of mild traumatic brain injury: role of biochemical markers in diagnosis of brain damage. Med Res Rev, 2014. 34(3): p. 503-31.
  23. Papa, L., S. Silvestri, G.M. Brophy, P. Giordano, J.L. Falk, C.F. Braga, C.N. Tan, N.J. Ameli, J.A. Demery, N.K. Dixit, M.E. Mendes, R.L. Hayes, K.K. Wang, and C.S. Robertson, GFAP out-performs S100beta in detecting traumatic intracranial lesions on computed tomography in trauma patients with mild traumatic brain injury and those with extracranial lesions. J Neurotrauma, 2014. 31(22): p. 1815-22.
  24. Pritt, M.L., D.G. Hall, W.H. Jordan, D.W. Ballard, K.K. Wang, U.R. Muller, and D.E. Watson, Initial biological qualification of SBDP-145 as a biomarker of compound-induced neurodegeneration in the rat. Toxicol Sci, 2014. 141(2): p. 398-408.
  25. Ren, C., J. Guingab-Cagmat, F. Kobeissy, S. Zoltewicz, S. Mondello, M. Gao, A. Hafeez, N. Li, X. Geng, S.F. Larner, J. Anagli, R.L. Hayes, X. Ji, and Y. Ding, A neuroproteomic and systems biology analysis of rat brain post intracerebral hemorrhagic stroke. Brain Res Bull, 2014. 102: p. 46-56.
  26. Schober, M.E., D.F. Requena, L.J. Davis, R.R. Metzger, K.S. Bennett, D. Morita, C. Niedzwecki, Z. Yang, and K.K. Wang, Alpha II Spectrin breakdown products in immature Sprague Dawley rat hippocampus and cortex after traumatic brain injury. Brain Res, 2014. 1574: p. 105-12.
  27. Zhang, Z., J.S. Zoltewicz, S. Mondello, K.J. Newsom, Z. Yang, B. Yang, F. Kobeissy, J. Guingab, O. Glushakova, S. Robicsek, S. Heaton, A. Buki, J. Hannay, M.S. Gold, R. Rubenstein, X.C. Lu, J.R. Dave, K. Schmid, F. Tortella, C.S. Robertson, and K.K. Wang, Human traumatic brain injury induces autoantibody response against glial fibrillary acidic protein and its breakdown products. PLoS One, 2014. 9(3): p. e92698.
  28. Brophy, G.M., A.T. Mazzeo, S. Brar, O.L. Alves, K. Bunnell, C. Gilman, T. Karnes, R.L. Hayes, and R. Bullock, Exposure of cyclosporin A in whole blood, cerebral spinal fluid, and brain extracellular fluid dialysate in adults with traumatic brain injury. J Neurotrauma, 2013. 30(17): p. 1484-9.
  29. Cao, M., T.J. George, V. Prima, D. Nelson, and S. Svetlov, Argininosuccinate synthase as a novel biomarker for inflammatory conditions. Biomarkers, 2013. 18(3): p. 242-9.
  30. Cao, M., V. Prima, D. Nelson, and S. Svetlov, Composite fatty acid ether amides suppress growth of liver cancer cells in vitro and in an in vivo allograft mouse model. Cell Oncol (Dordr), 2013. 36(3): p. 247-57.
  31. Guingab-Cagmat, J.D., E.B. Cagmat, R.L. Hayes, and J. Anagli, Integration of proteomics, bioinformatics, and systems biology in traumatic brain injury biomarker discovery. Front Neurol, 2013. 4: p. 61.
  32. Massaro, A.N., A. Jeromin, N. Kadom, G. Vezina, R.L. Hayes, K.K. Wang, J. Streeter, and M.V. Johnston, Serum biomarkers of MRI brain injury in neonatal hypoxic ischemic encephalopathy treated with whole-body hypothermia: a pilot study. Pediatr Crit Care Med, 2013. 14(3): p. 310-7.
  33. Mondello, S., A. Buki, D. Italiano, and A. Jeromin, alpha-Synuclein in CSF of patients with severe traumatic brain injury. Neurology, 2013. 80(18): p. 1662-8.
  34. Okonkwo, D.O., J.K. Yue, A.M. Puccio, D.M. Panczykowski, T. Inoue, P.J. McMahon, M.D. Sorani, E.L. Yuh, H.F. Lingsma, A.I. Maas, A.B. Valadka, and G.T. Manley, GFAP-BDP as an acute diagnostic marker in traumatic brain injury: results from the prospective transforming research and clinical knowledge in traumatic brain injury study. J Neurotrauma, 2013. 30(17): p. 1490-7.
  35. Prima, V., M. Cao, and S.I. Svetlov, ASS and SULT2A1 are Novel and Sensitive Biomarkers of Acute Hepatic Injury-A Comparative Study in Animal Models. J Liver, 2013. 2(1).
  36. Prima, V., V.L. Serebruany, A. Svetlov, R.L. Hayes, and S.I. Svetlov, Impact of moderate blast exposures on thrombin biomarkers assessed by calibrated automated thrombography in rats. J Neurotrauma, 2013. 30(22): p. 1881-7.
  37. Ren, C., S. Zoltewicz, J. Guingab-Cagmat, J. Anagli, M. Gao, A. Hafeez, N. Li, J. Cao, X. Geng, F. Kobeissy, S. Mondello, S.F. Larner, R.L. Hayes, X. Ji, and Y. Ding, Different expression of ubiquitin C-terminal hydrolase-L1 and alphaII-spectrin in ischemic and hemorrhagic stroke: Potential biomarkers in diagnosis. Brain Res, 2013. 1540: p. 84-91.
  38. Tate, C.M., K.K. Wang, S. Eonta, Y. Zhang, W. Carr, F.C. Tortella, R.L. Hayes, and G.H. Kamimori, Serum brain biomarker level, neurocognitive performance, and self-reported symptom changes in soldiers repeatedly exposed to low-level blast: a breacher pilot study. J Neurotrauma, 2013. 30(19): p. 1620-30.
  39. Yokobori, S., R. Bullock, S. Gajavelli, S. Burks, S. Mondello, J. Mo, K.K. Wang, R.L. Hayes, H. Bramlett, and D. Dietrich, Preoperative-induced mild hypothermia attenuates neuronal damage in a rat subdural hematoma model. Acta Neurochir Suppl, 2013. 118: p. 77-81.
  40. Zoltewicz, J.S., S. Mondello, B. Yang, K.J. Newsom, F. Kobeissy, C. Yao, X.C. Lu, J.R. Dave, D.A. Shear, K. Schmid, V. Rivera, T. Cram, J. Seaney, Z. Zhang, K.K. Wang, R.L. Hayes, and F.C. Tortella, Biomarkers track damage after graded injury severity in a rat model of penetrating brain injury. J Neurotrauma, 2013. 30(13): p. 1161-9.
  41. Berger, R.P., R.L. Hayes, R. Richichi, S.R. Beers, and K.K. Wang, Serum concentrations of ubiquitin C-terminal hydrolase-L1 and alphaII-spectrin breakdown product 145 kDa correlate with outcome after pediatric TBI. J Neurotrauma, 2012. 29(1): p. 162-7.
  42. Cai, Y., H.X. Zhu, J.M. Li, X.G. Luo, P.R. Patrylo, G.M. Rose, J. Streeter, R. Hayes, K.K. Wang, X.X. Yan, and A. Jeromin, Age-related intraneuronal elevation of alphaII-spectrin breakdown product SBDP120 in rodent forebrain accelerates in 3xTg-AD mice. PLoS One, 2012. 7(6): p. e37599.
  43. Czeiter, E., S. Mondello, N. Kovacs, J. Sandor, A. Gabrielli, K. Schmid, F. Tortella, K.K. Wang, R.L. Hayes, P. Barzo, E. Ezer, T. Doczi, and A. Buki, Brain injury biomarkers may improve the predictive power of the IMPACT outcome calculator. J Neurotrauma, 2012. 29(9): p. 1770-8.
  44. Glushakova, O.Y., A. Jeromin, J. Martinez, D. Johnson, N. Denslow, J. Streeter, R.L. Hayes, and S. Mondello, Cerebrospinal fluid protein biomarker panel for assessment of neurotoxicity induced by kainic acid in rats. Toxicol Sci, 2012. 130(1): p. 158-67.
  45. Guingab-Cagmat, J.D., K. Newsom, A. Vakulenko, E.B. Cagmat, F.H. Kobeissy, S. Zoltewicz, K.K. Wang, and J. Anagli, In vitro MS-based proteomic analysis and absolute quantification of neuronal-glial injury biomarkers in cell culture system. Electrophoresis, 2012. 33(24): p. 3786-97.
  46. Mondello, S., A. Gabrielli, S. Catani, M. D'Ippolito, A. Jeromin, A. Ciaramella, P. Bossu, K. Schmid, F. Tortella, K.K. Wang, R.L. Hayes, and R. Formisano, Increased levels of serum MAP-2 at 6-months correlate with improved outcome in survivors of severe traumatic brain injury. Brain Inj, 2012. 26(13-14): p. 1629-35.
  47. Mondello, S., A. Jeromin, A. Buki, R. Bullock, E. Czeiter, N. Kovacs, P. Barzo, K. Schmid, F. Tortella, K.K. Wang, and R.L. Hayes, Glial neuronal ratio: a novel index for differentiating injury type in patients with severe traumatic brain injury. J Neurotrauma, 2012. 29(6): p. 1096-104.
  48. Mondello, S., J. Palmio, J. Streeter, R.L. Hayes, J. Peltola, and A. Jeromin, Ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) is increased in cerebrospinal fluid and plasma of patients after epileptic seizure. BMC Neurol, 2012. 12: p. 85.
  49. Papa, L., L.M. Lewis, J.L. Falk, Z. Zhang, S. Silvestri, P. Giordano, G.M. Brophy, J.A. Demery, N.K. Dixit, I. Ferguson, M.C. Liu, J. Mo, L. Akinyi, K. Schmid, S. Mondello, C.S. Robertson, F.C. Tortella, R.L. Hayes, and K.K. Wang, Elevated levels of serum glial fibrillary acidic protein breakdown products in mild and moderate traumatic brain injury are associated with intracranial lesions and neurosurgical intervention. Ann Emerg Med, 2012. 59(6): p. 471-83.
  50. Papa, L., L.M. Lewis, S. Silvestri, J.L. Falk, P. Giordano, G.M. Brophy, J.A. Demery, M.C. Liu, J. Mo, L. Akinyi, S. Mondello, K. Schmid, C.S. Robertson, F.C. Tortella, R.L. Hayes, and K.K. Wang, Serum levels of ubiquitin C-terminal hydrolase distinguish mild traumatic brain injury from trauma controls and are elevated in mild and moderate traumatic brain injury patients with intracranial lesions and neurosurgical intervention. J Trauma Acute Care Surg, 2012. 72(5): p. 1335-44.
  51. Svetlov, S.I., V. Prima, O. Glushakova, A. Svetlov, D.R. Kirk, H. Gutierrez, V.L. Serebruany, K.C. Curley, K.K. Wang, and R.L. Hayes, Neuro-glial and systemic mechanisms of pathological responses in rat models of primary blast overpressure compared to "composite" blast. Front Neurol, 2012. 3: p. 15.
  52. Yan, X.X., A. Jeromin, and A. Jeromin, Spectrin Breakdown Products (SBDPs) as Potential Biomarkers for Neurodegenerative Diseases. Curr Transl Geriatr Exp Gerontol Rep, 2012. 1(2): p. 85-93.
  53. Zoltewicz, J.S., D. Scharf, B. Yang, A. Chawla, K.J. Newsom, and L. Fang, Characterization of Antibodies that Detect Human GFAP after Traumatic Brain Injury. Biomark Insights, 2012. 7: p. 71-9.
  54. Berger, R.P., J.F. Houle, R.L. Hayes, K.K. Wang, S. Mondello, and M.J. Bell, Translating biomarkers research to clinical care: applications and issues for rehabilomics. PM R, 2011. 3(6 Suppl 1): p. S31-8.
  55. Brophy, G.M., S. Mondello, L. Papa, S.A. Robicsek, A. Gabrielli, J. Tepas, 3rd, A. Buki, C. Robertson, F.C. Tortella, R.L. Hayes, and K.K. Wang, Biokinetic analysis of ubiquitin C-terminal hydrolase-L1 (UCH-L1) in severe traumatic brain injury patient biofluids. J Neurotrauma, 2011. 28(6): p. 861-70.
  56. Guingab-Cagmat, J.D., S.M. Stevens, Jr., M.V. Ratliff, Z. Zhang, M.S. Gold, J. Anagli, K.K. Wang, and F.H. Kobeissy, Identification of tyrosine nitration in UCH-L1 and GAPDH. Electrophoresis, 2011. 32(13): p. 1692-705.
  57. Hayes, R.L., S. Mondello, and K. Wang, Glial fibrillary acidic protein: a promising biomarker in pediatric brain injury. Pediatr Crit Care Med, 2011. 12(5): p. 603-4.
  58. Liu, M.C., F. Kobeissy, W. Zheng, Z. Zhang, R.L. Hayes, and K.K. Wang, Dual vulnerability of tau to calpains and caspase-3 proteolysis under neurotoxic and neurodegenerative conditions. ASN Neuro, 2011. 3(1): p. e00051.
  59. Mondello, S., U. Muller, A. Jeromin, J. Streeter, R.L. Hayes, and K.K. Wang, Blood-based diagnostics of traumatic brain injuries. Expert Rev Mol Diagn, 2011. 11(1): p. 65-78.
  60. Mondello, S., L. Papa, A. Buki, M.R. Bullock, E. Czeiter, F.C. Tortella, K.K. Wang, and R.L. Hayes, Neuronal and glial markers are differently associated with computed tomography findings and outcome in patients with severe traumatic brain injury: a case control study. Crit Care, 2011. 15(3): p. R156.
  61. Prima, V., A. Wang, G. Molina, K.K. Wang, and S.I. Svetlov, Inhibition of LPS toxicity by hepatic argininosuccinate synthase (ASS): novel roles for ASS in innate immune responses to bacterial infection. Int Immunopharmacol, 2011. 11(9): p. 1180-8.
  62. Zhang, Z., S. Mondello, F. Kobeissy, R. Rubenstein, J. Streeter, R.L. Hayes, and K.K. Wang, Protein biomarkers for traumatic and ischemic brain injury: from bench to bedside. Transl Stroke Res, 2011. 2(4): p. 455-62.
  63. Cassar, S.C., A.E. Tovcimak, N.R. Rustay, T.A. Ellis, B.A. Hooker, D.G. Witte, J. Li, W.R. Buck, D. Scharf, U. Muller, A. Jeromin, K.K. Wang, and J.F. Waring, Comparing levels of biochemical markers in CSF from cannulated and non-cannulated rats. J Neurosci Methods, 2010. 192(2): p. 249-53.
  64. Liu, M.C., L. Akinyi, D. Scharf, J. Mo, S.F. Larner, U. Muller, M.W. Oli, W. Zheng, F. Kobeissy, L. Papa, X.C. Lu, J.R. Dave, F.C. Tortella, R.L. Hayes, and K.K. Wang, Ubiquitin C-terminal hydrolase-L1 as a biomarker for ischemic and traumatic brain injury in rats. Eur J Neurosci, 2010. 31(4): p. 722-32.
  65. Martinez, J.A., Z. Zhang, S.I. Svetlov, R.L. Hayes, K.K. Wang, and S.F. Larner, Calpain and caspase processing of caspase-12 contribute to the ER stress-induced cell death pathway in differentiated PC12 cells. Apoptosis, 2010. 15(12): p. 1480-93.
  66. Mondello, S., S.A. Robicsek, A. Gabrielli, G.M. Brophy, L. Papa, J. Tepas, C. Robertson, A. Buki, D. Scharf, M. Jixiang, L. Akinyi, U. Muller, K.K. Wang, and R.L. Hayes, alphaII-spectrin breakdown products (SBDPs): diagnosis and outcome in severe traumatic brain injury patients. J Neurotrauma, 2010. 27(7): p. 1203-13.
  67. Papa, L., L. Akinyi, M.C. Liu, J.A. Pineda, J.J. Tepas, 3rd, M.W. Oli, W. Zheng, G. Robinson, S.A. Robicsek, A. Gabrielli, S.C. Heaton, H.J. Hannay, J.A. Demery, G.M. Brophy, J. Layon, C.S. Robertson, R.L. Hayes, and K.K. Wang, Ubiquitin C-terminal hydrolase is a novel biomarker in humans for severe traumatic brain injury. Crit Care Med, 2010. 38(1): p. 138-44.
  68. Svetlov, S.I., V. Prima, D.R. Kirk, H. Gutierrez, K.C. Curley, R.L. Hayes, and K.K. Wang, Morphologic and biochemical characterization of brain injury in a model of controlled blast overpressure exposure. J Trauma, 2010. 69(4): p. 795-804.
  69. Zhang, Z., S.F. Larner, F. Kobeissy, R.L. Hayes, and K.K. Wang, Systems biology and theranostic approach to drug discovery and development to treat traumatic brain injury. Methods Mol Biol, 2010. 662: p. 317-29.
  70. Zhang, Z., V. Majava, A. Greffier, R.L. Hayes, P. Kursula, and K.K. Wang, Collapsin response mediator protein-2 is a calmodulin-binding protein. Cell Mol Life Sci, 2009. 66(3): p. 526-36.
  71. Zhang, Z., S.F. Larner, M.C. Liu, W. Zheng, R.L. Hayes, and K.K. Wang, Multiple alphaII-spectrin breakdown products distinguish calpain and caspase dominated necrotic and apoptotic cell death pathways. Apoptosis, 2009. 14(11): p. 1289-98.
  72. Svetlov, S.I., S.F. Larner, D.R. Kirk, J. Atkinson, R.L. Hayes, and K.K. Wang, Biomarkers of blast-induced neurotrauma: profiling molecular and cellular mechanisms of blast brain injury. J Neurotrauma, 2009. 26(6): p. 913-21.
  73. Oli, M.W., R.L. Hayes, G. Robinson, and K.K. Wang, Traumatic brain injury biomarkers: from pipeline to diagnostic assay development. Methods Mol Biol, 2009. 566: p. 293-302.
  74. Mazzeo, A.T., G.M. Brophy, C.B. Gilman, O.L. Alves, J.R. Robles, R.L. Hayes, J.T. Povlishock, and M.R. Bullock, Safety and tolerability of cyclosporin a in severe traumatic brain injury patients: results from a prospective randomized trial. J Neurotrauma, 2009. 26(12): p. 2195-206.
  75. Hayes, R.L., G. Robinson, U. Muller, and K.K. Wang, Translation of neurological biomarkers to clinically relevant platforms. Methods Mol Biol, 2009. 566: p. 303-13.
  76. Brophy, G.M., J.A. Pineda, L. Papa, S.B. Lewis, A.B. Valadka, H.J. Hannay, S.C. Heaton, J.A. Demery, M.C. Liu, J.J. Tepas, 3rd, A. Gabrielli, S. Robicsek, K.K. Wang, C.S. Robertson, and R.L. Hayes, alphaII-Spectrin breakdown product cerebrospinal fluid exposure metrics suggest differences in cellular injury mechanisms after severe traumatic brain injury. J Neurotrauma, 2009. 26(4): p. 471-9.
  77. Papa, L., G. Robinson, M. Oli, J. Pineda, J. Demery, G. Brophy, S.A. Robicsek, A. Gabrielli, C.S. Robertson, K.K. Wang, and R.L. Hayes, Use of biomarkers for diagnosis and management of traumatic brain injury patients. Expert Opin Med Diagn, 2008. 2(8): p. 937-45.
  78. Pineda, J.A., S.B. Lewis, A.B. Valadka, L. Papa, H.J. Hannay, S.C. Heaton, J.A. Demery, M.C. Liu, J.M. Aikman, V. Akle, G.M. Brophy, J.J. Tepas, K.K. Wang, C.S. Robertson, and R.L. Hayes, Clinical significance of alphaII-spectrin breakdown products in cerebrospinal fluid after severe traumatic brain injury. J Neurotrauma, 2007. 24(2): p. 354-66.
  79. Germano, A., M. Caffo, F.F. Angileri, F. Arcadi, J. Newcomb-Fernandez, G. Caruso, F. Meli, J.A. Pineda, S.B. Lewis, K.K. Wang, P. Bramanti, C. Costa, and R.L. Hayes, NMDA receptor antagonist felbamate reduces behavioral deficits and blood-brain barrier permeability changes after experimental subarachnoid hemorrhage in the rat. J Neurotrauma, 2007. 24(4): p. 732-44.
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