Ronald L. Hayes, PhD
Title:
Distinguished Research Fellow, Center for Innovative Research
Clinical Programs Director
Chairman, Board of Directors Banyan Biomarkers, Inc.
Education:
Ph.D., Virginia Commonwealth University
M.S., Virginia Commonwealth University
B.A., University of Richmond

Areas of Interest:
Pathophysiology of head trauma.Biochemical markers of brain injury.The psychology and physiology of consciousness and attention.Neurobiology of somatosensory perception with emphasis on the neural encoding and modulation of information about noxious stimuli.Central nervous system metabolism, blood flow and their functional correlates.

Existing/Pending Support:

EXISTING

Banyan Biomarkers, Inc.
2/1/03-2/28/10        ROLE: Principal Investigator
Funding Agency: DoD (US Army)
DAMD 17-03-1-0066, “Biochemical Markers of Brain Injury: An Integrated Proteomics-Based Approach”

Banyan Biomarkers, Inc.
1/15/07-12/31/11    ROLE: Principal Investigator
Funding Agency: NIH
R01 NS NS051431, “Unfolded Protein Response in Traumatic Brain Injury”

Banyan Biomarkers, Inc.
ROLE: Principal Investigator
Funding Date Pending
Funding Agency:  Congressional Initiative (with Univ of Pittsburgh)
“Biomarkers: Evaluating and Treating Acute and Chronic TBI”

Banyan Biomarkers, Inc.
12/01/05-12/31/07              ROLE: Mentor (PI is Kevin Wang)
Funding Agency: NIH
R21 NS052322, “Proteolytic Mechanisms of Axonal and Dendritic Damage”

Banyan Biomarkers, Inc.
3/31/04 - 4/30/09                ROLE: Co-Investigator (PI is Ming Cheng Liu)
Funding Agency: NIH
R01 NS049175, “Biochemical Basis of Axonal & Myelin Injury in Head Trauma”

University of Florida
8/7/06-8/6/08                      ROLE: Principal Investigator
Funding Agency: DoD (US Navy)
N00014-06-1-1029, “Biomarkers for Blast Induced Injury

University of Florida
7/26/06-4/30/11      ROLE: Principal Investigator
Funding Agency: NIH
R01 NS052831-01A1, “Biochemical Markers of Traumatic Brain Injury”


PENDING

University of Florida
4/1/06-3/31/10        ROLE: Co-Mentor (PI is Andrew K. Ottens)
Funding Agency: NIH
K25, “Dynamics of the TBI Degradome”


Recent Selected Publications:
Ottens AK, Golden EC, Bustamante L, Hayes RL, Denslow ND, Wang KK.
Proteolysis of multiple myelin basic protein isoforms after neurotrauma: characterization by mass spectrometry.
J Neurochem. 2007 Nov 22; [Epub ahead of print]
PMID: 18036155 [PubMed - as supplied by publisher]

Germanò A, Caffo M, Angileri FF, Arcadi F, Newcomb-Fernandez J, Caruso G, Meli F, Pineda JA, Lewis SB, Wang KK, Bramanti P, Costa C, Hayes RL.
NMDA receptor antagonist felbamate reduces behavioral deficits and blood-brain barrier permeability changes after experimental subarachnoid hemorrhage in the rat.
J Neurotrauma. 2007 Apr;24(4):732-44.
PMID: 17439355 [PubMed - indexed for MEDLINE]

Ottens AK, Kobeissy FH, Fuller BF, Liu MC, Oli MW, Hayes RL, Wang KK.
Novel neuroproteomic approaches to studying traumatic brain injury.
Prog Brain Res. 2007;161:401-18. Review.
PMID: 17618994 [PubMed - indexed for MEDLINE]

Pineda JA, Lewis SB, Valadka AB, Papa L, Hannay HJ, Heaton SC, Demery JA, Liu MC, Aikman JM, Akle V, Brophy GM, Tepas JJ, Wang KK, Robertson CS, Hayes RL.
Clinical significance of alphaII-spectrin breakdown products in cerebrospinal fluid after severe traumatic brain injury.
J Neurotrauma. 2007 Feb;24(2):354-66.
PMID: 17375999 [PubMed - indexed for MEDLINE]

Lewis SB, Velat GJ, Miralia L, Papa L, Aikman JM, Wolper RA, Firment CS, Liu MC, Pineda JA, Wang KK, Hayes RL.
Alpha-II spectrin breakdown products in aneurysmal subarachnoid hemorrhage: a novel biomarker of proteolytic injury.
J Neurosurg. 2007 Oct;107(4):792-6.
PMID: 17937225 [PubMed - indexed for MEDLINE]

Warren MW, Larner SF, Kobeissy FH, Brezing CA, Jeung JA, Hayes RL, Gold MS, Wang KK.
Calpain and caspase proteolytic markers co-localize with rat cortical neurons after exposure to methamphetamine and MDMA.
Acta Neuropathol. 2007 Sep;114(3):277-86. Epub 2007 Jul 24.
PMID: 17647000 [PubMed - indexed for MEDLINE]

Zhang Z, Ottens AK, Sadasivan S, Kobeissy FH, Fang T, Hayes RL, Wang KK.
Calpain-mediated collapsin response mediator protein-1, -2, and -4 proteolysis after neurotoxic and traumatic brain injury.
J Neurotrauma. 2007 Mar;24(3):460-72.
PMID: 17402852 [PubMed - indexed for MEDLINE]

Wang KK, Larner SF, Robinson G, Hayes RL.
Neuroprotection targets after traumatic brain injury.
Curr Opin Neurol. 2006 Dec;19(6):514-9. Review.
PMID: 17102687 [PubMed - indexed for MEDLINE]

Larner SF, Hayes RL, Wang KK.
Unfolded protein response after neurotrauma.
J Neurotrauma. 2006 Jun;23(6):807-29.
PMID: 16774469 [PubMed - indexed for MEDLINE]

Kobeissy FH, Ottens AK, Zhang Z, Liu MC, Denslow ND, Dave JR, Tortella FC, Hayes RL, Wang KK.
Novel differential neuroproteomics analysis of traumatic brain injury in rats.
Mol Cell Proteomics. 2006 Oct;5(10):1887-98. Epub 2006 Jun 26.
PMID: 16801361 [PubMed - indexed for MEDLINE]

Larner SF, McKinsey DM, Hayes RL, W Wang KK.
Caspase 7: increased expression and activation after traumatic brain injury in rats.
J Neurochem. 2005 Jul;94(1):97-108.
PMID: 15953353 [PubMed - indexed for MEDLINE]

Larner SF, Hayes RL, McKinsey DM, Pike BR, Wang KK.
Increased expression and processing of caspase-12 after traumatic brain injury in rats.
J Neurochem. 2004 Jan;88(1):78-90.
PMID: 14675152 [PubMed - indexed for MEDLINE]