Recent and Significant Publications
 
Ringger, N.C., O’Steen, B.E., Brabham, J.G., Silver, X., Pineda, J., Wang, K.K.W. and Hayes, R.L. (2005) A novel marker for traumatic brain injury: CSF αII-spectrin breakdown product levels. J. Neurotrauma 21, 1443–1456.

Larner, S.F., McKinsey, D.M., Hayes, R.L., Wang, K.K.W. (2005) Caspase-7: Increased Expression and Activation Following Traumatic Brain Injury in Rats. J. Neurochem. 94(1):97-108.

Wang, K.K.W.  Ottens, A., Liu, M.C., Lewis,  S.B., Meegan, C., Oli, M.W., Tortella, F.C., Hayes, R.L., (2005) "Proteomic identification of biomarkers of traumatic brain injury". Expert Reviews Proteomics 2(4):603-614.

Warren, M.W., Kobeissy, F.H.,  Hayes, R.L., Gold, M.S., Wang, K.K.W.  (2005) Concurrent calpain and caspase-3 mediated proteolysis of αII-spectrin and tau in rat brain after methamphetamine exposure: A similar profile to traumatic brain injury. Life Sciences 78: 301-309.

Ottens AK, Kobeissy FH, Golden EC, Zhang Z, Haskins WE, Chen SS, Hayes RL, Wang KKW, Denslow ND. (2006) Neuroproteomics in neurotrauma. Mass Spectrom. Rev. 25:380-408.

Liu M.C., Akle, V., Zheng, W.R., Dave, J.R., Tortella, F.C., Hayes, R.L., Wang, K.K.W.,  (2006) Comparing calpain- and caspase-3-degradation patterns in traumatic brain injury by differential proteome analysis. Biochem. J. 394,  715-725.

Warren, MW.  Zheng, W.R., Kobeissy , F., Liu, M.C.,, Hayes, R.L., Gold, Mark, M.C. Liu, and Wang, K.K.W. (2006) Calpain and caspase mediated proteolysis of αII-spectrin and tau in rat cerebrocortical neuron cultures after ecstasy (MDMA) or methamphetamine exposure Int. J. Neuropsypharm. 9, 1-11.

Sadasivan, S., Waghray, A., Larner, S.F., William A. Dunn, W.A. Jr., Hayes, R.L. and Wang, K.K.W. (2006).Amino Acid Starvation Induced Autophagic Cell Death in PC-12 Cells: Evidence for Activation of Caspase-3 but not Calpains. Apoptosis  11(9):1573-1582.

Liu^, M.C.,  Zheng, W.R.,  Kitlen, J.,, O’Steen, B.,  Flint, J. ,  Dave, J.R.,  Tortella F.C., Hayes, R.L.,  and Wang, K.K.W. (2006) Extensive myelin basic protein degradation in rat brain after traumatic brain injury. J. Neurochem.  98, 700-712.

Svetlov, S.I., Xiang, Y.W., Oli, M., Foley, D.P., Huang, G., Hayes, R.L., Ottens, A.K., Wang, K.K.W.  (2006) Identification and preliminary validation of novel biomarkers of acute hepatic ischemia/reperfusion injury using dual-platform proteomic/degradomic approaches. Biomarkers, 11: 355-369.

Kobeissy, F.H., Ottens, A.K., Zhang, Z.Q., Dave, J.R.,  Tortella F.C., Hayes, R.L. Wang, K.K.W. (2006) Differential proteomic analysis of traumatic brain injury biomarker study using CAX-PAGE/RPLC-MSMS method. Mo. Cell. Proteomics  5, Oct;5(10):1887-1898.

Wang, K.K.W. , Larner, S.F., Robinson, G., Hayes, R.L. (2006) Neuroprotection Targets After Traumatic Brain Injury. Current Opinion in Neurology, 19:514–519.

Ottens, A.K., Kobeissy, F., Fuller, B.F., ., Liu, M.C., Oli, M.W., R.L. Hayes, Wang, K.K.W. (2007) Novel neuroproteomic approaches to studying traumatic brain injury. Prog. Brain Res. 161C: 401-418.

Pineda, J., Liu, M.C., Aikman, J., Akle, V.,  Lewis, S.,  Wang, K.K.W., Robertson, C., Hayes, R.L. (2007) Clinical significance of αII-Spectrin Breakdown Products in CSF after Severe Traumatic Brain Injury in Human. J. Neurotrauma; 24: 354 -366.

Zhang, Z.Q., Ottens, A.K., Sadasivan, S., Kobeissy, F.H., Fang, T., Hayes, R.L., Wang, K.K.W. (2007) Calpain-mediated CRMP proteolysis in excitotoxic and traumatic brain injury. J. Neurotrauma 24(3) 460-472.

Ottens AK, Golden EC, Bustamante L, Hayes RL, Denslow ND, Wang KKW. Characterization of multi-isoform protein proteolysis by mass spectrometry after neurotrauma, J. Neurochem. 2007 Nov 22; [Epub ahead of print]

Lewis SB, Velat GJ, Miralia L, Papa L, Aikman JM, Wolper RA, Firment CS, Liu MC, Pineda JA, Wang KK, Hayes RL. (2007) Alpha-II spectrin breakdown products in aneurysmal subarachnoid hemorrhage: a novel biomarker of proteolytic injury. J Neurosurg. 107:792-796.